My puppies fly Pet first with Continental ,United ,American, Delta Airlines  They have done a great job at getting the pups to there new homes.
The cargo area is pressure and temperature controlled for safe transport. The pups are the last ones on and the first ones off.
We are at the mercy of the weather. Some of the airlines do have restriction .The temperatures must be no lower then 20 to30 degrees and temperatures can not exceed then 85 degrees except for Continental Airlines. Puppies are shipped out of Denver Colorado on Thursdays. You must be flexible. The cost is $265.00 that includes Flight, Kennel and Certificate to fly .The cost is for the lower USA For all other destinations I would be happy to give a quote on the flight.
I try to make it as easy on the pup as possible. I start preparing the pup for its flight by acclimating it to the crate so it realizes it is its safe place. The pups do travel well.